About pyrilutamide, the problem with how some people view it is that they see it as a finished product , like an object. You’ve got to step away from that kind of thinking and see pyrilutamide for what it really is, a chemical compound, a molecule .
This molecule has specific attributes, like being a selective AR antagonist with a 91.3% rate of AR inhibition .This high number is crucial, not just because it shows how well the drug binds to AR, but also because it affects how long it stays bound. A high affinity drug like pyrilutamide is more likely to remain attached longer, reducing the chances of DHT binding to that receptor.
DHT affects your hair mainly through an “indirect effect.” Just because DHT binds very effectively to the AR receptor doesn’t mean much by itself, the real issue is how it influences cellular processes once it binds.If you naturally have low DHT levels, or you’re using something to reduce DHT in your scalp, this will greatly benefit pyrilutamide.
IC50
In the body, DHT and testosterone compete to bind to androgen receptors, the IC50 shows how well a drug can outcompete these natural hormones for the receptor. This information is very important for determining the drug’s effectiveness and the amount needed to achieve the desired result .
When talking about the IC50 of DHT, it’s not as simple as saying a fixed number like “0.2.” Usually, the IC50 for DHT is reported as a range, often between 0.25 and 0.50. This happens because of natural differences in biological variability…
Pyrilutamide has an IC50 of 0.28, and if we compare this to the lower end of the DHT range, which is 0.25, the values are quite close . This suggests that pyrilutamide and DHT have similar binding affinities for androgen receptors, even though it’s not exactly the same, the small difference suggests that pyrilutamide can effectively compete with DHT.
Side effects
As we discussed earlier, the binding affinity of a molecule affects how long it stays attached to the receptor . Pyrilutamide’s metabolite has a very weak affinity for AR receptors, this means that even if the metabolite binds to some receptors, it is less likely to cause significant side effects.
Concentration
The basic idea is that with a higher concentration of a drug, more drug molecules are available to enter the cells. With more molecules available, the rate at which drug molecules enter the cells increases.
If there are more drug molecules bound to targets and/or less competition from other molecules, the drug may stay inside the cell longer.
Inside a cell, there’s only so much space available, and this capacity depends on factors like the cell’s size and the size of the molecules involved, pyrilutamide is larger than DHT, so it takes up more room.
When you introduce more of pyrilutamide, the cell will eventually reach a point where it can’t take in anymore. Even after it’s inside, there’s still a limit to how many molecules can be kept before they’re broken down or expelled… the cell has mechanisms to handle excessive amounts by metabolizing them or pumping them out.
Kintor " 1% has significantly increased the retention concentration of the tincture on human scalp cells compared to the KX-826 tincture 0.5%"
The 1% concentration leads to better receptor saturation and longer lasting effects, so it’s more effective at reaching and maintaining higher drug levels inside the cells, which enhances its impact and effectiveness.
Should you buy the 0.5% concentration? If you have mild hair loss, the 0.5% might be sufficient and worth trying. I’ve heard some impressive results from the 12-month trial of the 0.5%, but keep in mind that I can’t guarantee the info is 100% accurate.
Yes, it’s pricey, I paid $210 for a 3-month supply. While it’s not cheap, it’s not a significant amount for me personally. Your financial situation will play a big role in whether or not it’s worth it for you, so you’ll need to make that call yourself…
You might be able to find it cheaper from China, somewhere around $120 for 180ml of the 0.5% concentration. I’m not entirely sure about this, as I’m not familiar with buying from China through these kinds of services, but that’s what I’ve heard.
So when I say I like pyrilutamide, I’m referring to the molecule itself. I agree that the study results aren’t groundbreaking, but any drug that only shows maintenance results in a short period is likely to struggle in clinical trials for androgenic alopecia.
If the information I’ve heard about the 12-month safety trial is accurate, the drug might show more than just maintenance results if used for over 6 months. The numbers reportedly look quite impressive after another 6 months of use. However, it might be wise to wait for Kintor’s press release on this study before deciding whether to buy the product at this concentration. The next press release should be out in about 8 days.
Thanks for taking the time to read this.
