Precise pharmacology to my knowledge. Always check against a potential error though:
@craggg can you pin this like you did with fuzzasteride’s dutateride calculator. it is not very easy to find and while not very important for hair loss still interesting imho.
Minoxidil (Oral route) → SULT1A1 → Minoxidil Sulfate → Opening of potassium channels → Closure of Voltage Gated Calcium Channels → Hyperpolarization of cell membranes → Reduction of intracellular calcium (ca2+) → Decrease in formation of calcium calmoludin protein-ligand complex → Reduced activation of myosin light chain kinase → Reduced phosphorylation of the myosin light chains → (this is where minoxidil differentiates, blood pressure vs hair growth medicine) Failure to contract vascular smooth muscles → Relaxation of arterioles → Significant drop in blood pressure (typically at high dose only though, eg. well above 5mg).
-baldbutnotbold (the og is back, a bit different but back
)