Minoxidil's mechanism of action on blood pressure as a potassium channel opening molecule

Precise pharmacology to my knowledge. Always check against a potential error though:

@craggg can you pin this like you did with fuzzasteride’s dutateride calculator. it is not very easy to find and while not very important for hair loss still interesting imho.

Minoxidil (Oral route) → SULT1A1 → Minoxidil SulfateOpening of potassium channelsClosure of Voltage Gated Calcium ChannelsHyperpolarization of cell membranesReduction of intracellular calcium (ca2+)Decrease in formation of calcium calmoludin protein-ligand complexReduced activation of myosin light chain kinaseReduced phosphorylation of the myosin light chains(this is where minoxidil differentiates, blood pressure vs hair growth medicine) Failure to contract vascular smooth musclesRelaxation of arteriolesSignificant drop in blood pressure (typically at high dose only though, eg. well above 5mg).

-baldbutnotbold (the og is back, a bit different but back :slight_smile: )