Is using 5% minoxidil + 0.1% topical finasteride once daily almost as effective as twice daily?

Hi everyone,

I’m in my late 20’s male with early Norwood 3 hair loss (receding temples and slight crown thinning). I recently started using 5% minoxidil + 0.1% finasteride topical solution.

Right now, I’m applying 1 mL twice a day, which means I’m applying about 2 mg/day of topical finasteride.

My main concern is systemic absorption of finasteride. From what I’ve read, many dermatologists prescribe topical finasteride once daily, and minoxidil has a long enough scalp residence time that once-daily use may still be effective.

For those who have experience with this:

  • Did you notice any difference in results when switching from twice daily to once daily?

  • Is once-daily 1 mL enough to maintain good results, especially when using a combination of minoxidil and finasteride?

  • Has anyone switched to once daily specifically to reduce systemic exposure while still getting good regrowth?

I’d especially appreciate hearing from people who’ve used the same 5% minoxidil + 0.1% finasteride combination for 6–12 months.

Thanks!