All of these “ignore @henryk” responses are funny but please be more thoughtful before making overly confident replies like “topical dut is not very effective”. There is real research that shows you’re wrong. Bear in mind the delivery mechanisms of topicals has variance, as in the case with dut with options like liposomal and mesotheraputic. But yes, topical is less effective than oral, which is why I listed it separately. The tradeoff is far less systemic involvement, especially with dut, which is important to most people.