Best of Tressless Roundup

December 2024 – End of Month

Research in hair loss and regrowth explores linoleic acid for hair growth via WNT/β-catenin pathways and 5α-reductase inhibition, with LA-rich oils showing promise. Carrot seed oil thickens hair roots and tips, while parsley leaf fractions act as anti-alopecia agents. Drug delivery innovations include nanostructured lipid carriers for fucoidan extract penetration and spironolactone nano-formulations for hyperandrogenic disorders. Polymeric nanoparticles enhance traditional treatment delivery to follicles. Platelet-rich plasma (PRP) is supported for hair restoration, while low-dose oral minoxidil offers effective personalized treatment. Stem cells and hair follicle dermal papilla cell spheroids show potential for regeneration, despite cell effectiveness challenges. Gut microbiota and androgenetic alopecia link suggests specific bacteria influence hair loss risk. CXCL12 is a target for androgen-induced hair loss, with androgens increasing CXCL12 expression, causing miniaturization. Saw palmetto is noted for anti-androgenic properties in androgenetic alopecia. Case studies show tirzepatide aids folliculitis decalvans regrowth, and baricitinib causes hair whitening in alopecia universalis. Ritlecitinib improves regrowth in severe alopecia areata patients switching from baricitinib.

Concerns over gynecomastia drive interest in alternatives like dutasteride and microneedling. Combining oral Vitamin D with topical minoxidil is being tested to enhance hair density, alongside ketoconazole shampoo in holistic regimens. Emerging treatments spark debate, with PP405 and Pelage’s stem cell activation under scrutiny. Risks like minoxidil’s pet toxicity and RU58841’s severe side effects are also hot topics. The community is fervently exploring new therapies, including sugar gels and moringa extract, in the quest for effective solutions.