July 2025 – End of Month
Exosome therapy and stem cell-derived exosomes show promise for androgenetic alopecia, with a case series and systematic review supporting increased hair density. Baricitinib regrew hair in a child with alopecia totalis due to a KRT74 variant, while dupilumab enhanced regrowth in alopecia areata, despite potential hair loss. Minoxidil aids regrowth post-antibody-drug conjugate treatment. Platelet-rich plasma is viable alongside minoxidil, with a meta-analysis confirming its efficacy for androgenic alopecia. Natural treatments like perilla seed extract and spirulina extract inhibit 5α-reductase and promote growth. Recombinant type XVII collagen stimulates growth via Wnt/β-Catenin and SHH/GLI pathways. A deep learning model aids early androgenetic alopecia detection, while TGF-β signaling is key in follicle regeneration. Female pattern hair loss involves B cell-related immune activation. 5α-reductase inhibitors are crucial, though side effects warrant caution.
The community discusses balancing hair loss treatments and health, particularly the switch between finasteride and dutasteride due to their differential DHT modulation and side effects. Concerns over oral finasteride’s side effects prompt exploration of topical alternatives, while debates rage on the efficacy of minoxidil for hairline-specific regrowth. Hormonal treatments like TRT and HCG are considered for those experiencing side effects from standard therapies. Nutritional factors, such as vitamin deficiencies, are scrutinized for their impact on hair health, with anecdotal evidence supporting the benefits of correcting these imbalances. Transgender individuals face unique challenges in managing hair loss during hormone replacement therapy, necessitating personalized approaches. The long-term use of minoxidil and finasteride raises concerns about dependency, prompting users to seek advice on regimen adjustments. These discussions underscore the quest for effective hair loss solutions that harmonize with overall health.