June 2025 – First Half
Oral JAK inhibitors show promise for alopecia areata, though relapse and side effects remain issues. In androgenetic alopecia, combination therapies are more effective, but safe, standardized treatments are still needed. Fractional lasers combined with topical therapies offer a promising and safe hair loss treatment. The HFE hair transplant method is noted for its effectiveness and safety, providing natural results with quick recovery for men. Metal nanoparticles are being explored for hair loss treatment, though safety assurances are necessary. In hair care products, a botanical extract-infused shampoo and tonic improved hair loss in androgenetic alopecia participants. A study on topical clove oil and minoxidil in testosterone-induced alopecic mice suggested clove oil might aid hair growth similarly to minoxidil, pending further human testing. Advances in hair shaft proteomics, focusing on cuticular keratins, have enhanced protein extraction and analysis, benefiting biomedical and forensic applications. The discovery of the sugar molecule 2dDR offers potential for hair regrowth in male pattern baldness.
The community is buzzing about transitioning from oral to topical finasteride with minoxidil to mitigate mental side effects like brain fog and mood changes, while the effectiveness of minoxidil is debated, prompting some to add finasteride despite side effects. Concerns about dosage and application methods for topicals are prevalent as users optimize routines. There’s exploration of switching from finasteride to dutasteride with mixed reports on libido and erections. Research highlights minoxidil response bottlenecks, focusing on sulfation and transport roles, and exploring tretinoin to enhance efficacy. Users address allergies and intolerances to treatment ingredients, seeking alternatives like alcohol-free formulations. Experiences with microneedling are shared, often integrated with vitamin supplementation to address deficiencies, reflecting a collective effort to navigate hair loss treatments and seek advice on results and strategy changes.