May 2025 – End of Month
Advancements in hair loss research reveal promising treatments: curcumin-primed milk-derived extracellular vesicles remodel the hair follicle microenvironment, while mesenchymal stem cell-derived exosomes rival minoxidil in efficacy. Rat hair follicle stem cell-derived exosomes highlight exosome-based therapies for skin regeneration. Natural compounds like DHHB from Platycladus orientalis L. and oxyresveratrol emerge as potential alternatives, with 1′S-1′-Acetoxychavicol acetate reducing testosterone-induced alopecia. Hyperbranched polymer dots activate Wnt/β-catenin for drug-free hair growth, and borate-modified recombinant type XVII collagen microneedles with IGF-1 offer new androgenetic alopecia treatments. Erbium lasers improve hair growth with minimal side effects. Caffeine and adenosine in shampoos may alter scalp microbiomes to enhance growth, while microbial dysbiosis serves as a diagnostic tool. Emerging therapies like Crown-X and mesotherapy show potential, though protocol standardization is needed. TNF-α blockers and IL inhibitors improve symptoms of dissecting cellulitis of the scalp.
The community discusses finasteride regimens, combining oral and topical forms to mitigate side effects and enhance efficacy, with some opting for topical finasteride to protect liver health, while others explore stacking oral and topical finasteride with Enclomiphene. Users report side effects like pelvic discomfort, prompting dosage adjustments, and are keen on understanding hair shedding during treatment, noting persistent hair loss despite long-term finasteride and minoxidil use, and debating if finasteride-induced hair loss is temporary or a sign of ineffectiveness. Beyond finasteride, the community explores treatment options for hair thinning, including microneedling with varied needle sizes and frequencies, and ketoconazole and ciclopirox shampoos for scalp health. Timing treatments around events like weddings to avoid shedding is also considered. The community evaluates alternative treatments like Ruderma and the impact of starting TRT on hair health, reflecting a collective effort to navigate hair loss treatments by sharing experiences and optimizing regimens.