February 2025 – First Half
Research in hair loss and regrowth explores hair follicle transplantation for wound healing and skin conditions, while polynucleotides show promise in androgenetic alopecia (AGA) without serious side effects. GLP-1 receptor agonists may cause hair loss but aid wound healing. The Retinoic-Acid-Related Orphan Receptor Alpha regulates seasonal hair molting, and unhealthy diet and lifestyle increase female AGA risk. Topical minoxidil has new side effects, while caffeine shows potential despite methodological flaws. A personalized multimodal treatment improves AGA, and the Hippo pathway maintains hair follicle cell stemness. Lipids promote growth via HIF-1 signaling, and pressure alopecia is linked to injectable treatments. 5-alpha reductase inhibitors with minoxidil are safe for male AGA, and a topical finasteride spray offers a new delivery method. Frontal fibrosing alopecia in men needs better diagnostics, and adrenal tumors link to hair loss in women. Mitochondria play a role in hair follicle development, with therapies targeting mitochondrial function. Melatonin affects hair growth dose-dependently, and RNase L represses follicle regeneration. A review on alopecia treatments highlights targeted therapies and personalized approaches, with JAK inhibitors and regenerative medicine innovations promising improved outcomes.
The community discusses finasteride experiences, noting both benefits and side effects, with some users reporting initial success followed by shedding, prompting consideration of dutasteride. Young users focus on age-related experiences and peer advice, while discussions also touch on natural remedies like onion juice and pumpkin seeds, though minoxidil and RU58841 dominate. Users explore treatment regimens with the “big 3”, with some opting for hair transplants. Interest in research and development includes rhamnose, and PP405 in Phase 2b trials and potential FDA approval of Breezula, a weaker alternative to finasteride and minoxidil. Users share progress pictures showing regrowth with finasteride and minoxidil, while some try unconventional methods like scalp burning, though traditional treatments prevail.